The study of their properties of complexes of the acids based on the components of the root of Zhuzgun

Abstract

: Zhuzgun - this is a unique desert plant containing a variety of substances used for medicinal purposes-alkaloids,
flavonoids,phenol carbonic acids, leucoanthocyanidins and other substances. The main component of the root of Calligonum
(Zhuzgun) - glycyrrhizin acid has its own antiviral activity, based on the induction of interferon formation. The article reflects
the results of the study of a complex compound of glycyrrhizin acid with remantadine-an anti-influenza drug. The obtained
new complex compounds: acid glycyrrhizin (KG) of rimantadine — kaliteden; acid 18-digidropiridinovmi (K18 - DGL) with
rimantadine - caliraman. The structure of the complex compounds obtained by IR and NMR spectroscopy is established. The
absorption bands belonging to the protonated amino group ( NH+
3
) were found in the spectra of the obtained compounds. In
these compounds detected pronounced activity against influenza virus A and reasonable in relation to influenza virus, whereas
rimantadine are active only against influenza a virus. a Distinctive feature of complex compounds from each other is that
kaliteden for antiviral activity only slightly inferior to callimanco, but to reduce the acute toxicity and hepatotoxicity than
recent. In the future, we plan to study all’italiana hepatoprotectoare activity