Reaction of butanedione cyclization with urea and methylureas

Abstract

At this time, the chemistry of heterocyclic compounds is one of the most developed areas of organic chemistry.
Of particular interest are glycoluryls, which can act as biologically active and medicinal substances. Among the glycoluril
derivatives, preparations are known which have been used as medicaments, antioxidants and explosives. Among the many
glycoluryl derivatives, N-methyl derivatives have a broad spectrum of biological activity. Consequently, they are promising
compounds for study. In this study, for the purpose of obtaining azaheterocycles, reactions of urea and methylureas’ with
butanedione have been shown which lead to novel N-methyl glycoluril derivatives that are attractive as carriers of useful
properties. The results of the preparation of N-methyl derivatives of glycoluril are shown in the article.