Development of methods for separation and identification of the spatial isomers of N, N’-dimethylglycoluril

Abstract

At present, chemistry of heterocyclic compounds is one of the developing branches of chemistry, in particular,
glycolurils and their derivatives are of particular interest. The glycoluril derivatives have a wide range of biological activity.
They are used as psychotropic drugs. Dimethylglycoluryl isomers can be prepared by synthesis from methylurea and glyoxal.
Each isomer has its specificity of action. The isomers of N, N’-dimethylglycoluril exhibit different biological properties. By
way of example, 2,6-disubstituted isomers are much more likely than 2,4-disubstituted to exhibit psychotropic activity. There is
no specific information in the literature on the separation and identification of isomers of N, N’-dimethylglycoluryl derivatives,
which makes them interesting for study. Therefore, new methods of chromatographic separation and identification of N, N’-
dimethylglycoluryl derivatives have been developed.