Methods for synthesis of phosphorylated glycolurils

Abstract

Phosphorus-containing compounds have found widespread use across diverse fields. In agriculture, these compounds serve as pesticides, and their application as flame retardants is well-documented. In the realm of medicine, they exhibit potential as antitumor drugs and antibiotics, while within the human body, phosphorus-containing compounds play integral roles in various enzymes. Compounds with phosphorus linked to the nitrogen atom through carbon have garnered significant attention from researchers, offering the possibility of generating phosphorus-containing analogs of amino acids. These compounds can function as flame retardants or showcase biological activity.

Concurrently, the chemistry of cyclic urea has experienced rapid development in various domains, primarily attributed to its accessibility and multifunctionality. A progressive avenue in glycoluryl chemistry involves the synthesis and exploration of phosphorus-containing compounds derived from it. The combination of urea fragments and phosphoryl groups in the molecule imparts specific and beneficial properties to the resulting substance. This integration is extensively discussed in methods for obtaining phosphorylated urea.

This article delves into the principal applications of glycolurils and their derivatives. Additionally, it compiles and examines various methodologies for synthesizing phosphorylated glycoluryl derivatives. The analysis extends to existing literature data on the synthesis and properties of numerous organophosphorus glycolurils.