Chlorinated sesquiterpenoides isolated from plant sources

Abstract

Sesquiterpene lactones are compounds of interest in terms of structure and properties that are widely distributed in the plant world, forming the largest group of secondary metabolites. Sesquiterpene lactones are characterized by highly bioavailability, including anti-inflammatory, antibacterial, antifungal, antimalarial,  antileishmaniasis activities, as well as antitumor and cytotoxic effects. There have been identified representatives of the anti-HBV activity in the study. Significant attention should be paid to the fact that they are based on promising medical drugs or medications. This short review article collected data on sesquiterpene lactones containing a halogen atom. According to the studies carried out, it has been observed that compounds with a halogen atom found in nature usually contain a chlorine atom. As for the structural features, it has been found that most halogen sesquiterpene lactones released from natural sources are guaiano-structured, also found in the form of seco-guaianolide and germacranolide. In addition, the article determines their biological activity, in particular, anti-fungal, anti-inflammatory, anti-cancer, antiradical, melanogenesis and tyrosinase activity, cytotoxicity.