Influence of acute combined intoxication with zinc, copper and arsenic salts on the biochemical blood indicators of animals

Abstract

: This article indicates the investigation results after studying the effects of acute combined intoxication with zinc
and copper, zinc and arsenic, copper and arsenic salts, used on the experimental animals. It is known that heavy metals after
entering human body disrupt the work of organs and systems. Since the complex of substances is often influencing the body,
it is necessary to study the combined effect of heavy metals, allowing to diagnose various diseases associated with heavy metals
toxic poisoning. There was also studied the biochemical composition of the poisoned animals blood plasma. The concentration
of such indicators as total protein, glucose, alanine aminotransferase, aspartate aminotransferase, total bilirubin, and creatinine
were determined. As toxicants, there were used the solutions of copper sulfate, zinc sulphate and sodium arsenite, which were
once intragastrically injected. Blood was collected the next day after the injection. As a result of our studies, it was found that
acute combined intoxication with zinc, copper and arsenic salts leads to the decrease in the content of total protein, glucose, in
the activity of aminotransferases, also it leads to the increase of total bilirubin and creatinine. It was shown that acute combined
intoxication with salts of zinc and copper, zinc and arsenic affects liver cells, and the same intoxication with copper and arsenic
salts affect to the cardiovascular system negatively